Benzimidazole Derivative Synthesis via Visible Light Photo-Redox: An Eco-Friendly Path to Bioactive Heterocyclic
Swatantra Bajpai1, Nidhi Srivastava2
1Swatantra Bajpai, Research, Department of Chemistry, P.P.N. P.G. College, Kanpur (Uttar Pradesh), India.
2Dr. Nidhi Srivastava, Professor, Department of Chemistry, P.P.N. P.G. College, Kanpur (Uttar Pradesh), India.
Manuscript received on 29 May 2026 | First Revised Manuscript received on 08 June 2026 | Second Revised Manuscript received on 11 June 2026 | Manuscript Accepted on 15 June 2026 | Manuscript published on 30 June 2026 | PP: 1-6 | Volume-12 Issue-10, June 2026 | Retrieval Number: 100.1/ijbsac.J054412100526 | DOI: 10.35940/ijbsac.J0544.12100626
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© The Authors. Published By: Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Using visible-light-induced photo-redox catalysis, a sustainable and environmentally friendly method for the synthesis of benzimidazole-based heterocyclic compounds has been established. Under green LED irradiation (λ = 535 nm, 18 W) in tetrahydrofuran (THF) at room temperature, the procedure uses Eosin Y as an effective, metal-free photosensitizer. Eosin Y (1 mol%) and THF performed best, according to optimization experiments, yielding the target product 2-(furan-2-yl)-1H benzimidazole in an isolated yield of 82% after 70 minutes. The process involves photoexcitation of Eosin Y, generation of radicals, and subsequent formation of a benzimidazole derivative via a single-electron transfer (SET) pathway. IR, ¹H NMR, ¹³C NMR, and ESI-MS investigations verified the product structure. This green LED-mediated technology has several advantages over traditional thermal approaches, including great atom economy, energy efficiency, metal-free operation, and quicker reaction times.
Keywords: Eosin-Y photo Redox Process, Benzimidazole Photo Redox Reaction, Heterocycles, Bioactive Substances, Green Chemistry, and Visible Light.
Scope of the Article: Organic Chemistry