Introduction To Solid Lipid Nano Particles- An Overview
Divya Sanganabhatla1, R. Shyam Sunder2, Harshit Malpani3
1Divya Sanganabhatla, Research Scholar, University College of Technology, Osmania University, Hyderabad (Telangana)- 500007, India. Professor,
2R Shyam Sunder, Principal, University College of Technology, Osmania University, Hyderabad (Telangana)- 500007, India.
3Harshit Malpani, Co-Reviewer, Guru Nanak Institutions School of Pharmacy, Ibrahimpatnam (Telangana)-501506, India.
Manuscript received on April 01, 2018. | Revised Version Manuscript Received on April 16, 2018. | Manuscript published on April 20, 2018. | PP: 1-4 | Volume-2 Issue-4, April 2018. | Retrieval Number: D0072042418
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Abstract: Solid lipid nanoparticles are of major importance to the developing field of nano technology with applications in drug delivery, research and clinical medicine and other sciences. SLN dispersions have been proposed as a new type of colloidal drug carrier system suitable for intravenous administration. Solid lipid nanoparticles are submicron colloidal carriers composed of a single lipid core matrix that is solid at body temperature, and is coated with a surfactant acting as stabilizer. The conventional approaches such as use of permeation enhancers, surface modification, prodrug synthesis, complex formation and colloidal lipid carrier based strategies have been developed for the delivery of drugs to intestinal lymphatics. Aspects of solid lipid nanoparticles route of administration and their bio distribution are also incorporated. If appropriately investigated, solid lipid nanoparticles may open new vistas in therapy of complex diseases. It also discusses the potential of SLNs in brain targeting
Keywords: Nano Particles, Solid Lipid Nanoparticles (SLNs), TEM, PCS, Bio Distribution.